Doctors Steve and Hannah Alexander, the duo behind the Alexander Lab, have spent the past 26 years at the University of Missouri. The Alexander Lab, founded in 1987, focused on developmental biology until the late nineties. Since then, the lab has studied DNA repair and drug resistance in cancer cells. With their current work, they hope to contribute to our ability to successfully treat cancers of all types, by providing insights into the biological process by which tumors develop resistance to anticancer drugs.
The Alexanders describe how mutations give cancer cells a growth advantage and why physicians often treat cancer with multiple chemotherapy drugs.
Since its foundation in 1987, the Alexander Lab has shifted from its original focus on developmental biology; it now studies how cells become resistant to chemotherapy drugs.
The Alexanders, whose lab originally studied developmental biology, describe how they were introduced to the chemotherapy drug cisplatin, which changed their course of their research to chemotherapy resistance.