He calls it “fire in the gut.” It’s the excitement, the burning drive to work through a problem and see the solution. It’s staying up at night, turning something over and over in your head and feeling exhilarated when you finally come up with an answer, says Chris Hardin, Professor and Chair of the Nutritional Sciences Department.
Take a good, hard mental image of a long line of people stretched for blocks. If you expand the line to roughly 100,000, this is the number of people waiting for an organ transplant. The imbalanced patient-to-organ ratio leaves many to die while waiting their turn. In response, some researchers try to tap into animal organs to save human lives, but those organs do not always work.
Research in the University of Missouri’s Division of Animal Sciences may help solve this medical debacle by using genetic modification. When an organ goes from one animal to another (like to a human), preexisting antibodies in the human bind to the organ’s sugar molecules and kill the organ, making it useless. “When you take a pig cell and transfer it to a human, the molecule is immediately recognized as foreign,” explains MU’s Animal Science Professor, Randall Prather. “Within minutes you’ll get hyperacute rejection, and the cells will be destroyed.”
Hardin’s research will have a number of applications down the road. His first project will affect the way we understand and treat diabetes. His second will help individuals taking drugs called statins to alleviate high cholesterol. He hopes to find some indicator in the human body that will tell whether the particular statins a patient takes are doing permanent damage to his/her muscles.
Chris Hardin has two principal lines of research in his laboratory. The first is a close examination of the way the human body metabolizes sugar, which Hardin has been examining for twenty years. For the second and more recent project, Hardin seeks to develop a better way to determine whether certain drugs associated with statin-therapy (for high cholesterol) are causing dangerous muscle pain and weakness.
Prather has contributed to research associated with modifying genes to produce healthy bacon. In a study involving the University of Pittsburgh’s School of Medicine, researchers transferred a gene known as fat-1 to fetal pig cells. The fat-1 gene creates an enzyme that converts omega-6 fatty acids to omega-3 fatty acids, the type of fatty acid known to reduce heart disease and cancer. As a collaborator in the research, Prather cloned the pig fetal cells containing the gene that makes omega-3 fatty acids and creates pigs with their their own omega-3 fatty acids.